Genetic risk scores and hallucinations in patients with Parkinson disease.

Abstract

OBJECTIVE:

We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of hallucinations in PD.

METHODS:

We used 2 population-based studies (ParkWest, Norway, and Parkinson's Environment and Gene, USA) providing us with 399 patients with PD with European ancestry and a PD diagnosis after age 55 years to assess the associations between 4 PRSs and hallucinations after 5 years of mean disease duration. Based on the existing genome-wide association study of other large consortia, 4 PRSs were created: one each using AD, SZ, and PD cohorts and another PRS for height, which served as a negative control.

RESULTS:

A higher prevalence of hallucinations was observed with each SD increase of the AD-PRS (odds ratio [OR]: 1.37, 95% confidence interval [CI]: 1.03-1.83). This effect was mainly driven by APOE (OR: 1.92, 95% CI: 1.14-3.22). In addition, a suggestive decrease and increase, respectively, in hallucination prevalence were observed with the SZ-PRS and the PD-PRS (OR: 0.77, 95% CI: 0.59-1.01; and OR: 1.29, 95% CI: 0.95-1.76, respectively). No association was observed with the height PRS.

CONCLUSIONS:

These results suggest that mechanisms for hallucinations in PD may in part be driven by the same genetic architecture that leads to cognitive decline in AD, especially by APOE.

• Authors: Cynthia D J Kusters, Kimberly C Paul, Aline Duarte Folle, Adrienne M Keener, Jeff M Bronstein, Valerija Dobricic, Ole-Bjørn Tysnes, Lars Bertram, Guido Alves, Janet S Sinsheimer, Christina M Lill, Jodi Maple-Grødem, Beate R Ritz
• Journal: Neurology. Genetics (Neurol Genet) Vol. 6 Issue 5 Pg. e492 (Oct 2020) ISSN: 2376-7839 [Print] United States
• PMID: 32802953 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.