Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health. The development of a vaccine is urgently needed for the prevention and control of COVID-19. Here, we report the pilot-scale production of an inactivated SARS-CoV-2 vaccine candidate (BBIBP-CorV) that induces high levels of neutralizing antibodies titers in mice, rats, guinea pigs, rabbits, and nonhuman primates (cynomolgus monkeys and rhesus macaques) to provide protection against SARS-CoV-2. Two-dose immunizations using 2 μg/dose of BBIBP-CorV provided highly efficient protection against SARS-CoV-2 intratracheal challenge in rhesus macaques, without detectable antibody-dependent enhancement of infection. In addition, BBIBP-CorV exhibits efficient productivity and good genetic stability for vaccine manufacture. These results support the further evaluation of BBIBP-CorV in a clinical trial.

• Authors: Hui Wang, Yuntao Zhang, Baoying Huang, Wei Deng, Yaru Quan, Wenling Wang, Wenbo Xu, Yuxiu Zhao, Na Li, Jin Zhang, Hongyang Liang, Linlin Bao, Yanfeng Xu, Ling Ding, Weimin Zhou, Hong Gao, Jiangning Liu, Peihua Niu, Li Zhao, Wei Zhen, Hui Fu, Shouzhi Yu, Zhengli Zhang, Guangxue Xu, Changgui Li, Zhiyong Lou, Miao Xu, Chuan Qin, Guizhen Wu, George Fu Gao, Wenjie Tan, Xiaoming Yang
• Journal: Cell (Cell) Vol. 182 Issue 3 Pg. 713-721.e9 (08 06 2020) ISSN: 1097-4172 [Electronic] United States
• PMID: 32778225 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• COVID-19 Vaccines
• Vaccines, Inactivated
• Viral Vaccines

Topics

• Animals
• Antibodies, Neutralizing (immunology)
• Antibodies, Viral (immunology)
• Betacoronavirus (genetics, immunology)
• COVID-19
• COVID-19 Vaccines
• Chlorocebus aethiops
• Coronavirus Infections (prevention & control, virology)
• Disease Models, Animal
• Drug Evaluation, Preclinical (methods)
• Female
• Guinea Pigs
• Immunogenicity, Vaccine
• Macaca fascicularis
• Macaca mulatta
• Male
• Mice
• Mice, Inbred BALB C
• Pandemics (prevention & control)
• Phylogeny
• Pneumonia, Viral (prevention & control, virology)
• Rabbits
• Rats
• Rats, Wistar
• SARS-CoV-2
• Vaccines, Inactivated (adverse effects, therapeutic use)
• Vero Cells
• Viral Vaccines (adverse effects, therapeutic use)