GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (≤ 3 cm).

Abstract

The significance of the polypeptide N-acetyl-galactosaminyl transferase-3 (GalNAc-T3) and mucin 1 (MUC1) in solitary pulmonary adenocarcinoma (SPA) initially diagnosed as malignant solitary pulmonary nodule (≤ 3 cm), especially as a combined predictor of prognosis and recurrence, was explored in this study. A retrospective analysis of 83 patients with SPA (≤ 3 cm), which revealed postoperative pathological diagnosis was lung adenocarcinoma after complete resection. Immunohistochemical staining was used to detect the expression of GalNAc-T3 and MUC1 in primary tumor specimens. The relationship between expression and various clinicopathological factors was analyzed, as well as the effects of patients' overall survival (OS) and disease-free survival (DFS). In all patients, GalNAc-T3 was highly expressed in 53 (63.9%) cases; MUC1 was highly expressed in 31 (37.3%) cases. The GalNAc-T3 expression was correlated with differentiation, pathological risk group, N stage, and TNM stage. The group with high GalNAc-T3 expression and low MUC1 expression (GalNAc-T3Hig/MUC1Low) is correlated to pathological differentiation and has a trend related to the TNM stage. The patients with better differentiation, lower pathological risk group, lower N stage, and GalNAc-T3 high expression had better overall survival, especially the GalNAc-T3Hig/MUC1Low group. Moreover, the moderate differentiation, N3 stage, and GalNAc-T3Hig/MUC1Low group were independent predictive factors for OS. Besides, patients with lower N stage, lower TNM stage, higher GalNAc-T3 expression got better disease-free survival (DFS), especially the GalNAc-T3Hig/MUC1Low group. The GalNAc-T3Hig/MUC1Low group was an independent predictive factor for DFS. In conclusion, GalNAc-T3 and MUC1 were combined predictors of prognosis and recurrence in SPA (≤ 3 cm).

• Authors: Qiang Xie, Fengzhou Li, Shilei Zhao, Tao Guo, Zhuoshi Li, Lei Fang, Shiqing Wang, Wenzhi Liu, Chundong Gu
• Journal: Human cell (Hum Cell) Vol. 33 Issue 4 Pg. 1252-1263 (Oct 2020) ISSN: 1749-0774 [Electronic] Japan
• PMID: 32776306 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• MUC1 protein, human
• Mucin-1
• N-Acetylgalactosaminyltransferases
• polypeptide N-acetylgalactosaminyltransferase

Topics

• Adenocarcinoma of Lung (diagnosis, genetics, pathology)
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis, genetics)
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Gene Expression
• Humans
• Lung Neoplasms (diagnosis, genetics, pathology)
• Male
• Middle Aged
• Mucin-1 (analysis, genetics)
• N-Acetylgalactosaminyltransferases (analysis, genetics)
• Neoplasm Recurrence, Local (diagnosis, genetics, pathology)
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Solitary Pulmonary Nodule (diagnosis)