Individual and combined effects of GSTM1 and GSTT1 polymorphisms on colorectal cancer risk: an updated meta-analysis.

Abstract

BACKGROUND:

The presence or absence of glutathione S-transferase M1 gene (GSTM1) and glutathione S-transferase T1 gene (GSTT1) polymorphisms, and their combined effects have been suggested as a risk factor for colorectal cancer (CRC). However, the results are inconsistent.

OBJECTIVES:

An updated meta-analysis was performed to solve the controversy.

METHODS:

Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines were used.

RESULTS:

Overall, the GSTM1 null genotype was associated with an increased CRC risk in Caucasians (odds ratio (OR) = 1.14, 95% confidence interval (CI): 1.05-1.23), Asians (OR = 1.19, 95% CI: 1.08-1.32), high-quality studies (OR = 1.12, 95% CI: 1.06-1.18). Moreover, the GSTM1 null genotype was also associated with an increased colon cancer risk (OR = 1.32, 95% CI: 1.16-1.51). The GSTT1 null genotype was also associated with an increased CRC risk in Asians (OR = 1.08, 95% CI: 1.02-1.15) and Caucasians (OR = 1.24, 95% CI: 1.09-1.41). Moreover, The GSTT1 null genotype was associated with an increased rectal cancer risk (OR = 1.13, 95% CI: 1.01-1.27, I2 = 8.3%) in subgroup analysis by tumor location. Last, the GSTM1 null/GSTT1 null genotype was associated with an increased CRC risk in Asians.

CONCLUSION:

This meta-analysis indicates that the GSTM1 and GSTT1 null genotypes are associated with increased CRC risk in Asians and Caucasians, and the GSTM1 null/GSTT1 null genotype was associated with increased CRC risk in Asians.

• Authors: Liang Song, Chen Yang, Xiao-Feng He
• Journal: Bioscience reports (Biosci Rep) Vol. 40 Issue 8 (08 28 2020) ISSN: 1573-4935 [Electronic] England
• PMID: 32776111 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2020 The Author(s).

Chemical References

• Biomarkers, Tumor
• glutathione S-transferase M1
• glutathione S-transferase T1
• Glutathione Transferase

Topics

• Humans
• Asian People (genetics)
• Biomarkers, Tumor (genetics)
• Case-Control Studies
• Colorectal Neoplasms (diagnosis, ethnology, genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Glutathione Transferase (genetics)
• Observational Studies as Topic
• Polymorphism, Genetic
• Risk Assessment
• Risk Factors
• White People (genetics)