RIFM fragrance ingredient safety assessment, tetrahydro-α-pentylfurfuryl acetate, CAS Registry Number 67634-08-6.

Abstract

The existing information supports the use of this material as described in this safety assessment. Tetrahydro-α-pentylfurfuryl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that tetrahydro-α-pentylfurfuryl acetate is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class III material, and the exposure to tetrahydro-α-pentylfurfuryl acetate is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; tetrahydro-α-pentylfurfuryl acetate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; tetrahydro-α-pentylfurfuryl acetate was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

• Authors: A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton Jr, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 144 Suppl 1 Pg. 111622 (Oct 15 2020) ISSN: 1873-6351 [Electronic] England
• PMID: 32771451 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Perfume

Topics

• Animals
• Dermatitis, Phototoxic
• Humans
• Mutagenicity Tests
• Perfume (toxicity)
• Registries
• Risk Assessment