Should bariatric surgery be offered for hepatocellular adenomas in obese patients?

Abstract

BACKGROUND:

Obesity and metabolic syndrome are increasingly recognized as risk factors for development of hepatocellular adenoma (HCA). The implications of weight loss on HCA regression has not been previously reviewed.

OBJECTIVES:

To analyze the effects of surgical and nonsurgical weight loss on HCA.

SETTING:

University Tertiary Hospital.

METHODS:

Literature review of full-text articles from PubMed and Scopus on patients with HCA who underwent surgical or nonsurgical weight loss was performed. Only English language articles were included and editorial comments were excluded. Wilcoxon signed rank test was used for paired data analysis. Spearman correlation was used for correlation between percent excess weight loss (%EWL) and number and size of HCA lesions.

RESULTS:

Out of 4 studies, 7 patients were included in this review, all of whom were female. The median preintervention body mass index was 41 kg/m2 compared with the postintervention body mass index of 28 kg/m2 (P = .002). The %EWL following intervention positively correlated to reduction in number of HCA lesions (%) postintervention, with a Spearman correlation of .78 (P = .04). Similarly, %EWL postintervention was positively correlated, though not statistically significant, to reduction in lesion size (%), with a Spearman correlation of .46 (P = .29). All patients who were candidates for liver resection preintervention based on lesion size > 5 cm avoided liver resection postintervention following surgical and nonsurgical weight loss.

CONCLUSIONS:

Effective long-term weight loss by surgical and nonsurgical methods result in regression of HCAs. Weight loss could avoid major liver resections or decrease the morbidity associated with liver surgery. Bariatric surgery should be considered as an option for management of surgically challenging HCAs in carefully selected obese patients. Multicenter long-term trials, while adjusting for cofounding factors, are required to determine the effects of surgical compared with nonsurgical weight loss on maintenance of HCA regression.

• Authors: Janindu Goonawardena, Chathri Ratnayake, King Tung Cheung, Adrian Fox
• Journal: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery (Surg Obes Relat Dis) Vol. 16 Issue 12 Pg. 2117-2124 (Dec 2020) ISSN: 1878-7533 [Electronic] United States
• PMID: 32771427 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

Topics

• Adenoma, Liver Cell (etiology, surgery)
• Bariatric Surgery
• Carcinoma, Hepatocellular
• Female
• Humans
• Liver Neoplasms (etiology, surgery)
• Male
• Multicenter Studies as Topic
• Obesity (complications, surgery)