Abstract |
l-3,4-dihydroxyphenylalanine ( l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and smoking behaviors revealed that the single-nucleotide polymorphism rs6640499, in the GPR143 gene, was associated with traits of smoking behaviors in Japanese individuals. In Gpr143 gene-deficient mice, nicotine-induced hypolocomotion and rewarding effect were attenuated compared to those in wild-type mice. Our findings suggest the involvement of GPR143 in the smoking behaviors.
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Authors | Daiki Masukawa, Daisuke Nishizawa, Kaori Kanai, Satoshi Kitamura, Yuka Kasahara, Tatsuo Hashimoto, Ryo Takahagi, Junko Hasegawa, Kyoko Nakayama, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Yoshio Goshima |
Journal | Journal of pharmacological sciences
(J Pharmacol Sci)
Vol. 144
Issue 2
Pg. 89-93
(Oct 2020)
ISSN: 1347-8648 [Electronic] Japan |
PMID | 32763057
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved. |
Chemical References |
- Eye Proteins
- GPR143 protein, human
- Gpr143 protein, mouse
- Membrane Glycoproteins
- Receptors, G-Protein-Coupled
- Receptors, Neurotransmitter
- levodopa receptor
- Nicotine
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Topics |
- Animals
- Asian People
- Eye Proteins
(genetics)
- Gene Deletion
- Genetic Association Studies
- Humans
- Male
- Membrane Glycoproteins
(genetics)
- Mice, Inbred C57BL
- Mice, Knockout
- Nicotine
(adverse effects)
- Polymorphism, Single Nucleotide
- Receptors, G-Protein-Coupled
(genetics)
- Receptors, Neurotransmitter
(genetics)
- Reinforcement, Psychology
- Severity of Illness Index
- Substance-Related Disorders
(genetics)
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