Abstract | OBJECTIVE: Up to 60% of women discontinue using the levonorgestrel-releasing intrauterine system (LNG-IUS) within 5 years because of bleeding irregularities, pain and/or systemic progestogenic adverse effects. The aim of the study was to assess treatment options for bleeding irregularities in women using the 52 mg LNG-IUS. METHODS: Database searches of Medline, Embase/Ovid and the Cochrane Library were carried out, and journals were searched by hand, for relevant studies published from database inception to March 2020. Inclusion criteria were randomised controlled trials (RCTs), prospective cohort studies and case-control studies of premenopausal women using the LNG-IUS and receiving medical treatment for bleeding irregularities. Screening, data extraction and quality assessment of retrieved articles were carried out independently by two pairs of reviewers. The primary outcome was the reduction of bleeding/ spotting days. RESULTS: CONCLUSION: Evidence for the medical treatment of (ongoing) bleeding irregularities during use of the LNG-IUS is lacking and more research is needed on the topic.
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Authors | P A H H van der Heijden, R M G Tibosch, P M A J Geomini, S Veersema, L M Bullens, E J L G Delvaux, B N Bui, M Y Bongers |
Journal | The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
(Eur J Contracept Reprod Health Care)
Vol. 25
Issue 6
Pg. 484-491
(Dec 2020)
ISSN: 1473-0782 [Electronic] England |
PMID | 32757842
(Publication Type: Journal Article, Systematic Review)
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Chemical References |
- Contraceptive Agents, Hormonal
- Cyclooxygenase Inhibitors
- Estrogens
- Estradiol
- Naproxen
- Levonorgestrel
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Topics |
- Contraceptive Agents, Hormonal
(adverse effects)
- Cyclooxygenase Inhibitors
(therapeutic use)
- Estradiol
(therapeutic use)
- Estrogens
(therapeutic use)
- Female
- Humans
- Intrauterine Devices, Medicated
(adverse effects)
- Levonorgestrel
(adverse effects)
- Menorrhagia
(drug therapy)
- Naproxen
(therapeutic use)
- Premenopause
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