Abstract | AIMS: METHODS AND RESULTS: In this nationwide observational cohort study, 26 606 patients who underwent urgent or emergent percutaneous coronary intervention (January 2011-December 2017) and initiated treatment with ticagrelor [N = 20 073 (75.5%); median age 64 years (25th-75th percentile 55-72 years); 74.8% men] or clopidogrel [N = 6533 (24.5%); median age 68 years (25th-75th percentile 58-77 years); 70.2% men] were identified using Danish nationwide registries. The 1-year standardized absolute risks of outcomes was calculated based on cause-specific Cox regression models, and average treatment effects between treatment groups were obtained as standardized differences in absolute 1-year risks. The absolute 1-year risk of SAB was 0.10% [95% confidence interval (CI), 0.05-0.15%] in the ticagrelor group and 0.29% (95% CI, 0.17-0.42%) in the clopidogrel group. Compared with clopidogrel, treatment with ticagrelor was associated with a significantly lower absolute 1-year risk of SAB [absolute risk difference -0.19% (95% CI, -0.32% to -0.05%), P value 0.006]. Likewise, treatment with ticagrelor was associated with a significantly lower absolute 1-year risk of sepsis [0.99% (95% CI, 0.83-1.14%) vs. 1.49% (95% CI, 1.17-1.80%); absolute risk difference -0.50% (95% CI, -0.86% to -0.14%), P value 0.007] and pneumonia [3.13% (95% CI, 2.86-3.39%) vs. 4.56% (95% CI, 4.03-5.08%); absolute risk difference -1.43% (95% CI, -2.03% to -0.82%), P value < 0.001] compared with clopidogrel. CONCLUSION:
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Authors | Jawad H Butt, Emil L Fosbøl, Thomas A Gerds, Kasper Iversen, Henning Bundgaard, Niels Eske Bruun, Anders R Larsen, Andreas Petersen, Paal S Andersen, Robert L Skov, Lauge Østergaard, Eva Havers-Borgersen, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Jonas B Olesen |
Journal | European heart journal. Cardiovascular pharmacotherapy
(Eur Heart J Cardiovasc Pharmacother)
Vol. 8
Issue 1
Pg. 13-19
(01 05 2022)
ISSN: 2055-6845 [Electronic] England |
PMID | 32750138
(Publication Type: Journal Article, Observational Study)
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Copyright | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: [email protected]. |
Chemical References |
- Platelet Aggregation Inhibitors
- Ticagrelor
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Topics |
- Acute Coronary Syndrome
(therapy)
- Aged
- Bacteremia
(diagnosis, drug therapy, epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(adverse effects)
- Staphylococcal Infections
(diagnosis, drug therapy, epidemiology)
- Staphylococcus aureus
- Ticagrelor
(adverse effects)
- Treatment Outcome
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