Efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in reducing inflammation around the teeth and implants: a randomized clinical trial.

Abstract

OBJECTIVES:

To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetylpyridinium chloride (CPC) mouth rinse, as an adjunct to professional plaque removal (PPR) and mechanical hygiene, in the treatment of peri-implant mucositis (PiM) and gingivitis.

MATERIAL AND METHODS:

Patients displaying PiM in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received PPR (at baseline and 6-month visits) and were instructed to rinse, twice daily, during 1 year with the tested mouth rinse or a placebo. Clinical and patient-reported outcomes were recorded at baseline and 6 and 12 months.

RESULTS:

Fifty-four patients were included in the study and 46 attended the final visit. In the teeth and implants with inflammation, a higher reduction in BOP was observed in the test group. Statistically significant differences between groups were only observed in the lingual sites of the teeth with gingivitis (mean difference = 11.96%; 95% confidence interval [1.09; 22.83]; p = 0.03). Overall, compliance and satisfaction were good, even though staining were higher for the test group (p < 0.05).

CONCLUSIONS:

The combined use of mechanical debridement with a 0.03% CHX and 0.05% CPC mouth rinse may have adjunctive benefits in the management of gingivitis, and it is associated with a higher degree of staining.

CLINICAL RELEVANCE:

The control of gingivitis can be improved, after professional mechanical debridement, with toothbrushing and the supplementary use of a 0.03% CHX and 0.05% CPC mouth rinse at home.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT03533166.

• Authors: Juan Bollain, Alberto Pulcini, Ignacio Sanz-Sánchez, Elena Figuero, Bettina Alonso, Mariano Sanz, David Herrera
• Journal: Clinical oral investigations (Clin Oral Investig) Vol. 25 Issue 4 Pg. 1729-1741 (Apr 2021) ISSN: 1436-3771 [Electronic] Germany
• PMID: 32737664 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Dental Implants
• Mouthwashes
• Cetylpyridinium
• Chlorhexidine

Topics

• Anti-Infective Agents, Local
• Cetylpyridinium (therapeutic use)
• Chlorhexidine
• Dental Implants
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Double-Blind Method
• Gingivitis (drug therapy, prevention & control)
• Humans
• Inflammation
• Mouthwashes