Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study.

Abstract

PURPOSE:

To examine the prospective association between serum Mg level and the incidence of cognitive impairment.

METHODS:

A random sub-cohort (n = 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75-0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.

RESULTS:

After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96), P for linear trend = 0.08].

CONCLUSIONS:

Findings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.

• Authors: Cheng Chen, Pengcheng Xun, Frederick Unverzagt, Leslie A McClure, Marguerite Ryan Irvin, Suzanne Judd, Mary Cushman, Ka He
• Journal: European journal of nutrition (Eur J Nutr) Vol. 60 Issue 3 Pg. 1511-1520 (Apr 2021) ISSN: 1436-6215 [Electronic] Germany
• PMID: 32737612 (Publication Type: Journal Article)

Chemical References

• Magnesium

Topics

• Cognition Disorders (epidemiology)
• Cognitive Dysfunction (epidemiology)
• Humans
• Incidence
• Magnesium
• Prospective Studies
• Race Factors
• Risk Factors
• Stroke (epidemiology)