Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia.

Abstract

The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

• Authors: Andrea Corbingi, Idanna Innocenti, Annamaria Tomasso, Raffaella Pasquale, Andrea Visentin, Marzia Varettoni, Elena Flospergher, Francesco Autore, Francesca Morelli, Livio Trentin, Gianluigi Reda, Dimitar G Efremov, Luca Laurenti
• Journal: British journal of haematology (Br J Haematol) Vol. 190 Issue 6 Pg. 901-908 (09 2020) ISSN: 1365-2141 [Electronic] England
• PMID: 32712965 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2020 British Society for Haematology and John Wiley & Sons Ltd.

Chemical References

• Immunoglobulin G
• Immunoglobulin M
• Neoplasm Proteins
• TP53 protein, human
• Tumor Suppressor Protein p53

Topics

• Adult
• Aged
• Aged, 80 and over
• Chromosome Deletion
• Chromosomes, Human, Pair 12
• Chromosomes, Human, Pair 17 (genetics)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Immunoglobulin G (blood, genetics)
• Immunoglobulin M (blood, genetics)
• Leukemia, Lymphocytic, Chronic, B-Cell (blood, genetics, mortality)
• Male
• Middle Aged
• Neoplasm Proteins (blood, genetics)
• Paraproteinemias (blood, genetics, mortality)
• Retrospective Studies
• Smith-Magenis Syndrome (blood, genetics, mortality)
• Survival Rate
• Trisomy
• Tumor Suppressor Protein p53 (genetics, metabolism)