Recent advances in the development of microparticles for pulmonary administration.

Abstract

Pulmonary drug delivery offers several benefits for the management of various conditions over other conventional routes. Inhalation of drugs can also be useful for targeting alveolar macrophages and for maintaining a higher drug concentration in the lung tissues to improve the efficacy of drugs and shorten the duration of treatment, thereby reducing drug toxicities. Thus, such an approach is useful in the treatment of various pulmonary and nonpulmonary diseases. Newer techniques and delivery devices have been used for the formulation of inhalable microparticles. Here. we not only focus on advances in inhalation therapy and in the preparation of microparticles, but also address the clinical development and regulatory aspects of such therapies.

• Authors: Harsha Jain, Arpita Bairagi, Saurabh Srivastava, Shashi Bala Singh, Neelesh Kumar Mehra
• Journal: Drug discovery today (Drug Discov Today) Vol. 25 Issue 10 Pg. 1865-1872 (10 2020) ISSN: 1878-5832 [Electronic] England
• PMID: 32712311 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Pharmaceutical Preparations

Topics

• Administration, Inhalation
• Chemistry, Pharmaceutical
• Drug Delivery Systems
• Drug Development (methods)
• Humans
• Lung (metabolism)
• Macrophages, Alveolar (metabolism)
• Microspheres
• Pharmaceutical Preparations (administration & dosage, metabolism)
• Tissue Distribution