Distinct Metabolomic Profile Because of Gestational Diabetes and its Treatment Mode in Women with Overweight and Obesity.

Abstract

OBJECTIVE:

Whether the presence of gestational diabetes (GDM) and its treatment mode influence the serum metabolic profile in women with overweight or obesity was studied.

METHODS:

The serum metabolic profiles of 352 women with overweight or obesity participating in a mother-infant clinical study were analyzed with a targeted NMR approach (at 35.1 median gestational weeks). GDM was diagnosed with a 2-hour 75-g oral glucose tolerance test.

RESULTS:

The metabolomic profile of the women with GDM (n = 100) deviated from that of women without GDM (n = 252). Differences were seen in 70 lipid variables, particularly higher concentrations of very low-density lipoprotein particles and serum triglycerides were related to GDM. Furthermore, levels of branched-chain amino acids and glycoprotein acetylation, a marker of low-grade inflammation, were higher in women with GDM. Compared with women with GDM treated with diet only, the women treated with medication (n = 19) had higher concentrations of severalizes of VLDL particles and their components, leucine, and isoleucine, as well as glycoprotein acetylation.

CONCLUSIONS:

A clearly distinct metabolic profile was detected in GDM, which deviated even more if the patient was receiving medical treatment. This suggests a need for more intense follow-up and therapy for women with GDM during pregnancy and postpartum to reduce their long-term adverse health risks.

• Authors: Kati Mokkala, Tero Vahlberg, Noora Houttu, Ella Koivuniemi, Kirsi Laitinen
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 28 Issue 9 Pg. 1637-1644 (09 2020) ISSN: 1930-739X [Electronic] United States
• PMID: 32705820 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

Topics

• Adult
• Diabetes, Gestational (metabolism, therapy)
• Female
• Humans
• Metabolomics (methods)
• Obesity (therapy)
• Overweight (therapy)
• Pregnancy