Elevated long noncoding RNA MALAT-1 expression is predictive of poor prognosis in patients with breast cancer: a meta-analysis.

Abstract

Accumulating evidence indicates that aberrant regulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long noncoding RNA (lncRNA), plays a vital role in tumorigenesis. However, its association with breast cancer has not been systematically evaluated. In the current study, a meta-analysis was conducted to clarify the association between MALAT-1 and the prognosis and clinicopathological features of breast cancer. Relevant literature published in several databases was searched. Hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were calculated to evaluate the effect of MALAT-1 expression on the survival outcomes and clinicopathological features of breast cancer. A total of 12 studies involving 4106 patients were identified. Pooled HR demonstrated that elevated MALAT-1 expression significantly predicted unfavorable overall survival (HR = 2.06, 95% CI: 1.66-2.56, P<0.0001) in patients with breast cancer. Subgroup analysis stratified by cancer type, sample size, and method of variance analysis also showed statistically significant associations. Additionally, the HR of patients with up-regulated MALAT-1 expression concerning disease-free survival (DFS), recurrence-free survival (RFS), and disease-specific survival (DSS) was 1.91 (95% CI: 1.53-2.39, P<0.0001). Further, elevated MALAT-1 expression was positively correlated with the progesterone receptor (PR) status (OR = 1.47, 95% CI: 1.18-1.82). Thus, MALAT-1 is a promising biomarker for predicting survival outcomes in patients with breast cancer.

• Authors: Yanyan Wang, Yujie Zhang, Kaimin Hu, Jili Qiu, Yue Hu, Meiqi Zhou, Suzhan Zhang
• Journal: Bioscience reports (Biosci Rep) Vol. 40 Issue 8 (08 28 2020) ISSN: 1573-4935 [Electronic] England
• PMID: 32700729 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
• Copyright: © 2020 The Author(s).

Chemical References

• Biomarkers, Tumor
• MALAT1 long non-coding RNA, human
• RNA, Long Noncoding

Topics

• Biomarkers, Tumor (genetics)
• Breast Neoplasms (genetics, mortality, pathology, therapy)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Prognosis
• RNA, Long Noncoding (genetics)
• Risk Assessment
• Risk Factors
• Up-Regulation