Abstract | BACKGROUND/AIMS: There is less acid burden in Chinese gastroesophageal reflux disease ( GERD) patients. However, the Lyon consensus proposed a higher threshold of acid exposure time ( AET > 6%) for GERD. The aims are to apply the updated criteria in Chinese GERD patients and clarify its influence on clinical outcome. METHODS: Patients who were referred for both esophageal high-resolution manometry and 24-hour esophageal pH monitoring due to reflux symptoms were retrospectively screened. Those patients with AET > 4% was included and grouped into either AET 4-6% or AET > 6%. Their manometric profile, reflux profile, and response to proton pump inhibitors (PPIs) were evaluated. Adjunctive evidence proposed in the Lyon consensus was added in patients with AET 4-6% for therapeutic gain. Another group of patients (n = 144) with AET < 4% were included as non- GERD patients. RESULTS: In total, 151 patients (102 males) were included with 113 patients AET > 6% (74.9%). GERD patients with AET > 4% were with more male, older patients, and higher body mass index compared with non- GERD patients. Meanwhile, GERD patients were less competent in esophagogastric junction pressure. However, the manometric and reflux profile were similar between patients with AET > 6% and 4-6%. The response rate of PPI therapy was 64.6% and 63.2%, respectively, in groups of AET > 6% and 4-6% (P > 0.05). When adjunctive evidence was added in patients with AET 4-6%, no therapeutic gain was obtained. CONCLUSIONS: The efficacy of PPI therapy was similar in patients with AET > 6% and 4-6%. The increase of the AET threshold did not influence the clinical outcome of Chinese GERD patients.
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Authors | Yuqing Lin, Yuwen Li, Mengya Liang, Niandi Tan, Mengyu Zhang, Songfeng Chen, Yinglian Xiao |
Journal | Journal of neurogastroenterology and motility
(J Neurogastroenterol Motil)
Vol. 27
Issue 1
Pg. 55-62
(Jan 30 2021)
ISSN: 2093-0879 [Print] Korea (South) |
PMID | 32699186
(Publication Type: Journal Article)
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