Abstract | AIMS: METHOD: Data were from Taiwan's National Health Insurance Research Database (NHIRD). The sample comprised individuals younger than 18 years with a diagnosis of ADHD (n = 90 634) in Taiwan's NHIRD between January 1996 and December 2013. We examined the cumulative effect of MPH on burn injury risk using Cox proportional hazards models. We conducted a sensitivity analysis for immortal time bias using a time-dependent Cox model and within-patient comparisons using the self-controlled case series model. RESULTS: Children with ADHD taking MPH had a reduced risk of burn injury, with a cumulative duration of treatment dose-related effect, compared with those not taking MPH. Compared with children with ADHD not taking MPH, the adjusted hazard ratio for burn injury was 0.70 in children taking MPH for <90 days (95% confidence interval (CI) 0.64-0.77) and 0.43 in children taking MPH for ≥90 days (95% CI 0.40-0.47), with a 50.8% preventable fraction. The negative association of MPH was replicated in age-stratified analysis using time-dependent Cox regression and self-controlled case series models. CONCLUSION: This study showed that MPH treatment was associated with a lower risk of burn injury in a cumulative duration of treatment dose-related effect manner.
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Authors | Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting Yu Kuo, Mong-Liang Lu, Wei-Ting Tseng, Tsai-Yu Hou, Jia-Ying Yeh, Charles Tzu-Chi Lee, Yi-Lung Chen, Min-Jing Lee, Michael E Dewey, Michael Gossop |
Journal | Epidemiology and psychiatric sciences
(Epidemiol Psychiatr Sci)
Vol. 29
Pg. e146
(Jul 20 2020)
ISSN: 2045-7979 [Electronic] England |
PMID | 32686635
(Publication Type: Journal Article)
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Chemical References |
- Central Nervous System Stimulants
- Methylphenidate
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Topics |
- Adolescent
- Attention Deficit Disorder with Hyperactivity
(drug therapy, epidemiology)
- Burns
(epidemiology, etiology, psychology)
- Central Nervous System Stimulants
(therapeutic use)
- Child
- Child, Preschool
- Female
- Humans
- Incidence
- Male
- Methylphenidate
(adverse effects, therapeutic use)
- Outcome Assessment, Health Care
- Proportional Hazards Models
- Retrospective Studies
- Risk
- Taiwan
(epidemiology)
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