Thrombosis and coagulopathy in COVID-19: An illustrated review.

Abstract

This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID-19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute-phase proteins, very high levels of D-dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID-19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).

• Authors: Marcel Levi, Beverley J Hunt
• Journal: Research and practice in thrombosis and haemostasis (Res Pract Thromb Haemost) Vol. 4 Issue 5 Pg. 744-751 (Jul 2020) ISSN: 2475-0379 [Electronic] United States
• PMID: 32685883 (Publication Type: Journal Article)
• Copyright: © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.