Abstract | AIMS: METHODS AND RESULTS: We examined the slopes of estimated glomerular filtration rate (eGFR) decline in the 2 years before vs. after an incident hospitalization with heart failure (HF) (n = 20 420), coronary heart disease (CHD) (n = 18 152), or stroke (n = 1808) using data from a complete laboratory data collection in Stockholm, Sweden between 2006 and 2011. eGFR slopes were estimated using mixed-effect models with unstructured residual correlation. Overall, incident hospitalization with HF and CHD, but not stroke, was significantly associated with a subsequent accelerated decline in eGFR, with a faster eGFR decline and greater slope change after HF than CHD. The pre-event vs. post-event eGFR slopes (mL/min/1.73 m2 per year) were -1.67 (-1.77 to -1.57) vs. -2.76 (-2.82 to -2.71), with a Δslope of -1.09 (-1.16 to -1.02) for HF; -1.09 (-1.20 to -0.98) vs. -1.87 (-1.92 to -1.81), with a Δslope of -0.78 (-0.85 to -0.70) for CHD; and -1.00 (-1.37 to -0.63) vs. -0.99 (-1.19 to -0.78), with a Δslope of 0.02 (-0.24 to 0.27) for stroke. The accelerated declines in eGFR after HF and CHD were consistent across the spectrum of eGFR, although pre-event eGFR slopes were steeper in lower eGFR (e.g. pre-event eGFR slope for HF -0.64 (-0.76 to -0.53) for eGFR ≥60 mL/min/1.73 m2 , -1.43 (-1.57 to -1.30) for eGFR 30-59 mL/min/1.73 m2 , and -2.42 (-2.71 to -2.12) for eGFR <30 mL/min/1.73 m2 ). CONCLUSIONS: Incident hospitalization with cardiac diseases (i.e. HF and CHD) was significantly associated with a subsequent acceleration of eGFR decline.
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Authors | Junichi Ishigami, Marco Trevisan, Lars H Lund, Tomas Jernberg, Josef Coresh, Kunihiro Matsushita, Juan-Jesus Carrero |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 22
Issue 10
Pg. 1790-1799
(10 2020)
ISSN: 1879-0844 [Electronic] England |
PMID | 32683762
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 European Society of Cardiology. |
Chemical References |
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Topics |
- Acceleration
- Cardiovascular Diseases
(epidemiology)
- Creatinine
- Glomerular Filtration Rate
- Heart Failure
(epidemiology)
- Hospitalization
- Humans
- Kidney
- Renal Insufficiency, Chronic
(epidemiology)
- Risk Factors
- Sweden
(epidemiology)
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