Abstract | BACKGROUND: METHODS: We conducted a prospective monocentric study among patients undergoing kidney transplantation at the University Hospital of Reims between May 2017 and April 2019. Intravesical pressure (IVP) was monitored every 8 h from Day 0 to 3. RESULTS: A total of 107 patients were enrolled. Among 55 patients included in the analysis, 74.5% developed IAH. Body mass index >25 kg/m2 was associated with IAH development {odds ratio [OR] 10.4 [95% confidence interval (CI) 2.0-52.9]; P = 0.005}. A previous history of peritoneal dialysis was protective [OR 0.06 (95% CI 0.01-0.3); P = 0.001]. IAH Grades III and IV occurred in 30.9% of patients and correlated with higher Day 3 creatininaemia (419.6 ± 258.5 versus 232.5 ± 189.4 μmol/L; P = 0.02), higher delayed graft function incidence (41.2 versus 7.9%; P = 0.04), lower Kirchner index measured using scintigraphy (0.47 ± 0.09 versus 0.64 ± 0.09; P = 0.0005) and decreased Day 30 estimated glomerular filtration rate (35.8 ± 18.8 versus 52.5 ± 21.3, P = 0.05). IAH patients had higher fluid balance (P = 0.02). Evolution of IVP correlated with weight gain (P < 0.01) and central venous pressure (P < 0.001). CONCLUSIONS: IAH is frequent after kidney transplantation and IAH Grades III and IV are independently associated with impaired graft function. These results question current haemodynamic objectives and raise for the first time interest in intra-abdominal pressure monitoring in these patients. CLINICAL TRIAL NOTATION: ClinicalTrials.gov identifier: NCT03478176.
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Authors | Vincent Dupont, Alexandre Debrumetz, Adrien Leguillou, David Morland, Alain Wynckel, Charlotte Colosio, Laetitia Mokri, Betoul Schvartz, Vincent Vuiblet, Stephane Larre, Coralie Barbe, Philippe Rieu |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 35
Issue 9
Pg. 1619-1628
(09 01 2020)
ISSN: 1460-2385 [Electronic] England |
PMID | 32678426
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. |
Topics |
- Female
- France
(epidemiology)
- Glomerular Filtration Rate
- Graft Rejection
(epidemiology, etiology, pathology)
- Hemodynamics
- Humans
- Incidence
- Intra-Abdominal Hypertension
(epidemiology, etiology, pathology)
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Prospective Studies
- Water-Electrolyte Balance
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