Anesthetic and analgesic effects of an opioid-free, injectable protocol in cats undergoing ovariohysterectomy: A prospective, blinded, randomized clinical trial.

Abstract

This study evaluated the effects of ketamine-dexmedetomidine-midazolam as part of an opioid-free, multimodal protocol in cats undergoing ovariohysterectomy. In a prospective, blinded, randomized clinical trial, cats received either 1 of 2 doses of ketamine [5 mg/kg body weight (BW), n = 10, K5 or 7 mg/kg BW, n = 13, K7] with midazolam (0.25 mg/kg BW) and dexmedetomidine (40 μg/kg BW) intramuscularly, intraperitoneal bupivacaine (2 mg/kg BW) and subcutaneous meloxicam (0.2 mg/kg BW) after surgery. Buprenorphine (0.02 mg/kg BW, intravenously) was administered if pain scores exceeded intervention scores with 2 pain scoring systems. Similar prevalence of rescue analgesia was observed (K5 = 6/10; K7 = 7/13) with significantly lower requirements in kittens (2/8) than adults (11/15). Tachypnea (K5 = 7/10 and K7 = 9/13) and desaturation (K5 = 3/10 and K7 = 4/13) were the 2 most common complications. Age influenced the prevalence of rescue analgesia. Most adult cats required opioids for postoperative pain relief.

• Authors: Truc Ngoc Diep, Beatriz P Monteiro, Marina C Evangelista, Aurelien Balleydier, Ryota Watanabe, Hélène L M Ruel, Graeme M Doodnaught, Thong Le Quang, Paulo V Steagall
• Journal: The Canadian veterinary journal = La revue veterinaire canadienne (Can Vet J) Vol. 61 Issue 6 Pg. 621-628 (06 2020) ISSN: 0008-5286 [Print] Canada
• PMID: 32675814 (Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)
• Copyright: Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.

Chemical References

• Analgesics, Opioid
• Anesthetics

Topics

• Analgesics, Opioid
• Anesthetics
• Animals
• Cat Diseases
• Cats
• Female
• Hysterectomy (veterinary)
• Ovariectomy (veterinary)
• Pain, Postoperative (drug therapy, prevention & control, veterinary)
• Prospective Studies