Abstract |
Nuclear receptors, liver X receptor-α (LXRα; NR1H3) and liver X receptor-β (LXRβ; NR1H2), are considered master regulators of lipid homeostasis. During the last couple of decades, their pivotal roles in several physiological and pathological processes ranging from energy supply, immunity, cardiovascular, neurodegenerative disorders and cancer have been highlighted. In this review, the main results achieved during more recent years about our understanding of the LXR involvement in cancer has been mainly obtained using small-molecule chemical probes. Remarkably, all these probes, albeit having different structure and biological properties, have a well demonstrated anti-tumoral activity arising from LXR modulation, indicating a high potential of LXR targeting for the treatment of cancer. LINKED ARTICLES: This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc.
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Authors | Lorenzo Pontini, Maura Marinozzi |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 178
Issue 16
Pg. 3261-3276
(08 2021)
ISSN: 1476-5381 [Electronic] England |
PMID | 32673401
(Publication Type: Journal Article, Review)
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Copyright | © 2020 The British Pharmacological Society. |
Chemical References |
- Liver X Receptors
- Receptors, Cytoplasmic and Nuclear
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Topics |
- Humans
- Liver X Receptors
- Neoplasms
(drug therapy)
- Neurodegenerative Diseases
- Receptors, Cytoplasmic and Nuclear
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