Diagnosis and management of Specific Antibody Deficiency.

Abstract

Specific antibody deficiency is a primary immunodeficiency disease recognized by the International Union of Immunology Societies and defined by recurrent respiratory infections with normal immunoglobulins, but diminished antibody responses to polysaccharide antigens after vaccination with the 23 valent pneumococcal polysaccharide vaccine. Clinical immunologists struggle with diagnosis and treatment, because the definition of an adequate response to immunization remains controversial. Specific antibody deficiency is managed clinically with close follow-up and prompt treatment of infections, antibiotic prophylaxis, or immune globulin therapy. Treatment is individualized using clinical judgment and existing practice guidelines, which will likely evolve as more studies become available.

• Authors: Elena E Perez, Mark Ballow
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 40 Issue 3 Pg. 499-510 (08 2020) ISSN: 1557-8607 [Electronic] United States
• PMID: 32654695 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Vaccines

Topics

• Agammaglobulinemia (complications, diagnosis, etiology, therapy)
• Clinical Decision-Making
• Combined Modality Therapy
• Disease Management
• Disease Susceptibility
• Humans
• Immunocompromised Host
• Infection Control
• Infections (diagnosis, etiology, therapy)
• Phenotype
• Primary Immunodeficiency Diseases (complications, diagnosis, etiology, therapy)
• Treatment Outcome
• Vaccination
• Vaccines (administration & dosage)