Optical coherence tomography angiography cyclic remodeling of CNV in patients affected by Best macular dystrophy.

Abstract

PURPOSE:

To evaluate the effect of photodynamic therapy and/or intravitreal injections on choroidal neovascularization in treatment-naïve patients affected by Best Macular Dystrophy using OCT-A.

MATERIALS AND METHODS:

BMD patients with CNV treated using PDT and/or IV were included in the study. All patients underwent a complete ophthalmological examination, OCT and 3 × 3 mm OCT-A. The OCT-A images were analyzed using an open-source software (ImageJ) to assess the CNV membrane area (CNV-MA), the CNV vessel area (CNV-VA), and vessel density (VD) at the follow-ups (3 months after PDT and 1 month after IV).

RESULTS:

Five eyes of four patients with CNV were included. All eyes received PDT as first-line therapy; 4 eyes underwent more than 1 treatment session: three eyes received 1 IV, whereas one eye had one further PDT. After PDT, the CNV-MA, CNV-VA, and VD quantitative parameters were obtained for four out of five eyes: in three eyes of two patients CNV-MA, CNV-VA, and VD first decreased and then gradually increased during follow-up, whereas in one eye of one patient CNV-MA, CNV-VA, and VD slightly increased. After IV the CNV-MA, CNV-VA, and VD had significantly decreased at the 1-month follow-up in three eyes of three patients.

CONCLUSION:

OCT-A is an important tool for the diagnosis of both naïve and fibrotic CNV in BMD patients; it is a non-invasive method for the qualitative and quantitative analysis of neovascular lesions during follow-up. Our results have shown a cyclic remodeling of treated CNV in BMD patients using both PDT and IV.

• Authors: Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio, Andrea Sodi, Ilaria Passerini, Francesca Cipollini, Gianni Virgili, Fabrizio Giansanti
• Journal: Ophthalmic genetics (Ophthalmic Genet) Vol. 41 Issue 5 Pg. 440-447 (10 2020) ISSN: 1744-5094 [Electronic] England
• PMID: 32643503 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Child
• Choroidal Neovascularization (diagnostic imaging, drug therapy, pathology)
• Female
• Fluorescein Angiography (methods)
• Humans
• Male
• Photochemotherapy (methods)
• Retrospective Studies
• Tomography, Optical Coherence (methods)
• Visual Acuity
• Vitelliform Macular Dystrophy (drug therapy, physiopathology)