Abstract | BACKGROUND: METHODS: Overview of systematic reviews of clinical trials comparing duloxetine and amitriptyline in the treatment of fibromyalgia. The reviews were screened in Cochrane, PubMed, EMBASE, and SRDR with no restrictions on language and year of publication, considering that the research was conducted in July 2018 and updated until May 2020. The selection was based on the following criteria: adult patients with a diagnosis of fibromyalgia treated with duloxetine or amitriptyline, comparing the efficacy and safety in pain, fatigue, sleep, and mood disorder symptoms and quality of life, in addition to the acceptability of these antidepressants. The methodological quality and strength of evidence were assessed using the AMSTAR and GRADE instruments. RESULTS: Eight systematic reviews were selected. Amitriptyline had low evidence for pain, moderate evidence for sleep and fatigue, and high evidence for quality of life. Duloxetine had high quality of evidence in patients with mood disorders. With low evidence, duloxetine has higher acceptability, but is safer in older patients, while amitriptyline is safer for non-elderly individuals. CONCLUSION: REGISTRATION: PROSPERO: CRD42019116101.
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Authors | Áurea Dias de Farias, Luciana Eberle, Tânia Alves Amador, Tatiane da Silva Dal Pizzol |
Journal | Advances in rheumatology (London, England)
(Adv Rheumatol)
Vol. 60
Issue 1
Pg. 35
(07 08 2020)
ISSN: 2523-3106 [Electronic] England |
PMID | 32641165
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antidepressive Agents
- Amitriptyline
- Duloxetine Hydrochloride
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Topics |
- Amitriptyline
(adverse effects, therapeutic use)
- Antidepressive Agents
(adverse effects, therapeutic use)
- Duloxetine Hydrochloride
(adverse effects, therapeutic use)
- Fibromyalgia
(drug therapy)
- Humans
- Syndrome
- Systematic Reviews as Topic
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