Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.

Abstract

INTRODUCTION:

Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS).

METHODS:

Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS).

RESULTS:

Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90.

DISCUSSION:

Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.

• Authors: Melissa E Petersen, Fan Zhang, Nicole Schupf, Sharon J Krinsky-McHale, James Hall, Mark Mapstone, Amrita Cheema, Wayne Silverman, Ira Lott, Michael S Rafii, Benjamin Handen, William Klunk, Elizabeth Head, Brad Christian, Tatiana Foroud, Florence Lai, H Diana Rosas, Shahid Zaman, Beau M Ances, Mei-Cheng Wang, Benjamin Tycko, Joseph H Lee, Sid O'Bryant, Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
• Journal: Alzheimer's & dementia (Amsterdam, Netherlands) (Alzheimers Dement (Amst)) Vol. 12 Issue 1 Pg. e12039 ( 2020) ISSN: 2352-8729 [Print] United States
• PMID: 32626817 (Publication Type: Journal Article)
• Copyright: © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.