Abstract |
Aim: To study the active targeting efficacy of phenylboronic acid-modified niclosamide solid lipid nanoparticles (PBA-Niclo-SLN) in triple-negative breast cancer (TNBC). Materials & methods: PBA-Niclo-SLNs were formulated by an emulsification- solvent evaporation method using PBA-associated stearylamine ( PBSA) as lipid. The drug uptake and the anticancer propensity of PBA-Niclo-SLN were studied in TNBC (MDA-MB231) cells and tumor-bearing mice. Results: PBA-Niclo-SLN formulation resulted in greater antitumor efficacy by inducing G0/G1 cell cycle arrest and apoptosis. Besides, PBA-Niclo-SLN effectively inhibited STAT3, CD44+/CD24- TNBC stem cell subpopulation, epithelial-mesenchymal transition markers. Besides, PBA-Niclo-SLN selectively accumulated at the tumor site with more significant tumor regression and improved the survivability in TNBC tumor-bearing mice. Conclusion: PBA-Niclo-SLN formulation would be an effective strategy to eradicate TNBC cells ( breast cancer stem cells and nonbreast cancer stem cells) efficiently.
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Authors | Sai Kiran Ss Pindiprolu, Praveen T Krishnamurthy, Venkata Rao Ghanta, Pavan Kumar Chintamaneni |
Journal | Nanomedicine (London, England)
(Nanomedicine (Lond))
Vol. 15
Issue 16
Pg. 1551-1565
(07 2020)
ISSN: 1748-6963 [Electronic] England |
PMID | 32618501
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Boronic Acids
- Lipids
- Niclosamide
- benzeneboronic acid
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Topics |
- Animals
- Apoptosis
- Boronic Acids
- Cell Line, Tumor
- Humans
- Lipids
- Mice
- Niclosamide
- Triple Negative Breast Neoplasms
(drug therapy)
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