Teriparatide Promotes Bone Healing in Medication-Related Osteonecrosis of the Jaw: A Placebo-Controlled, Randomized Trial.

Abstract

PURPOSE:

Medication-related osteonecrosis of the jaw (MRONJ) is an infrequent but morbid and potentially serious condition associated with antiresorptive and antiangiogenic therapies. Although MRONJ can be prevented by optimizing oral health, management of established cases is supportive and remains challenging. Teriparatide, an osteoanabolic agent that improves bone healing in preclinical studies and in chronic periodontitis, represents a potential treatment option.

PATIENTS AND METHODS:

In a double-blind, randomized, controlled trial, 34 participants with established MRONJ, with a total of 47 distinct MRONJ lesions, were allocated to either 8 weeks of subcutaneous teriparatide (20 µg/day) or placebo injections, in addition to calcium and vitamin D supplementation and standard clinical care. Participants were observed for 12 months, with primary outcomes that included the clinical and radiologic resolution of MRONJ lesions. Secondary outcomes included osteoblastic responses as measured biochemically and radiologically and changes in quality of life.

RESULTS:

Teriparatide was associated with a greater rate of resolution of MRONJ lesions (odds ratio [OR], 0.15 v 0.40; P = .013), and 45.4% of lesions resolved by 52 weeks compared with 33.3% in the placebo group. Teriparatide was also associated with reduced bony defects at week 52 (OR, 8.1; P = .017). The incidence of adverse events was balanced between groups, including nausea, anorexia, and musculoskeletal pain, most of mild severity.

CONCLUSION:

Teriparatide improves the rate of resolution of MRONJ lesions and represents an efficacious and safe treatment for it.

• Authors: Ie-Wen Sim, Gelsomina L Borromeo, Claudine Tsao, Rita Hardiman, Michael S Hofman, Christian Papatziamos Hjelle, Musib Siddique, Gary J R Cook, John F Seymour, Peter R Ebeling
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 38 Issue 26 Pg. 2971-2980 (09 10 2020) ISSN: 1527-7755 [Electronic] United States
• PMID: 32614699 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Bone Density Conservation Agents
• Teriparatide
• Denosumab

Topics

• Aged
• Bisphosphonate-Associated Osteonecrosis of the Jaw (drug therapy, etiology, pathology)
• Bone Density Conservation Agents (adverse effects)
• Denosumab (adverse effects)
• Double-Blind Method
• Female
• Humans
• Jaw (drug effects, pathology)
• Male
• Middle Aged
• Prospective Studies
• Teriparatide (adverse effects, therapeutic use)
• Time Factors
• Treatment Outcome
• Victoria
• Wound Healing (drug effects)