Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches.

Abstract

Chronic inflammation is the result a persistent increase in the expression of several proinflammatory pathways with impaired inflammatory resolution. Ectopic lymphoid organs (ELOs), untypical lymphoid annexes, emerge during chronic inflammation and contribute to the physiopathology of chronic inflammatory disorders. This review discusses the pathophysiological role of ELOs in the progression of immune-mediated inflammatory diseases (IMIDs), including multiple sclerosis (MS), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), atherosclerosis, and Sjögren syndrome (SSj). The molecular pathways underlying the emergence of ELOs are of interest for the development of novel pharmacological approaches for the management of chronic inflammatory diseases.

• Authors: Luca Antonioli, Matteo Fornai, Carolina Pellegrini, Stefano Masi, Ilaria Puxeddu, Corrado Blandizzi
• Journal: Trends in molecular medicine (Trends Mol Med) Vol. 26 Issue 11 Pg. 1021-1033 (11 2020) ISSN: 1471-499X [Electronic] England
• PMID: 32600794 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Cytokines

Topics

• Animals
• Biomarkers
• Cytokines (metabolism)
• Dendritic Cells (immunology, metabolism)
• Disease Management
• Disease Progression
• Disease Susceptibility
• Humans
• Immune System Diseases (diagnosis, drug therapy, etiology, metabolism)
• Lymphocyte Subsets (immunology, metabolism)
• Molecular Targeted Therapy
• Tertiary Lymphoid Structures (immunology, metabolism)