Abstract | PURPOSE: MATERIALS AND METHODS: This retrospective cohort study enrolled patients treated for stage II/III gastric cancer who developed tumor recurrence and in whom the MSI status or mismatch repair (MMR) status of the tumor was known. MSI status and the expression of MMR proteins were evaluated using polymerase chain reaction and immunohistochemical analysis, respectively. RESULTS: CONCLUSION: Patients with high MSI/MMR-deficient gastric cancer should be spared from adjuvant chemotherapy after surgery, but aggressive chemotherapy after recurrence should be considered. Higher tumor-node- metastasis stage, Lauren classification, interval to recurrence, and type of recurrence are associated with survival after tumor recurrence and should thus be considered when establishing a treatment plan and designing clinical trials targeting recurrent gastric cancer.
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Authors | Ji Yeong An, Yoon Young Choi, Jeeyun Lee, Woo Jin Hyung, Kyoung-Mee Kim, Sung Hoon Noh, Min-Gew Choi, Jae-Ho Cheong |
Journal | Cancer research and treatment
(Cancer Res Treat)
Vol. 52
Issue 4
Pg. 1153-1161
(Oct 2020)
ISSN: 2005-9256 [Electronic] Korea (South) |
PMID | 32599987
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Chemotherapy, Adjuvant
(adverse effects, methods)
- Clinical Decision-Making
- DNA Mismatch Repair
- Female
- Gastrectomy
- Humans
- Kaplan-Meier Estimate
- Male
- Microsatellite Instability
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis, genetics, mortality, therapy)
- Neoplasm Staging
- Prognosis
- Retrospective Studies
- Risk Assessment
(methods)
- Risk Factors
- Stomach
(pathology, surgery)
- Stomach Neoplasms
(diagnosis, genetics, mortality, therapy)
- Survival Analysis
- Time Factors
- Treatment Outcome
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