Abstract | BACKGROUND: METHODS: In the discovery population, 162 individuals diagnosed with type 2 diabetes and 162 matched controls from Beijing health management cohort were included. We analyzed the IgG glycan profile and composed a glycan score for type 2 diabetes. Findings were validated in the replication population from Beijing Xuanwu community cohort (280 cases and 508 controls). Area under curve (AUC) using 10-fold and bootstrap validation, net reclassification index (NRI), and integrated discrimination index (IDI) were calculated for the glycan score. RESULTS: In the discovery population, 5 initial IgG glycans and 7 derived traits were significantly associated with type 2 diabetes after Bonferroni correction and Lasso selection, which were validated in the replication population subsequently. The glycan score composed of these IgG glycans and traits showed a strong association with type 2 diabetes (combined odds ratio (OR): 3.78) and its risk factors. In the replication population, AUC of the model involving clinical traits improved from 0.74 to above 0.90, and the values of NRI and IDI were 0.35 and 0.42, respectively, with the glycan score added. CONCLUSIONS:
|
Authors | Zhiyuan Wu, Haibin Li, Di Liu, Lixin Tao, Jie Zhang, Baolu Liang, Xiangtong Liu, Xiaonan Wang, Xia Li, Youxin Wang, Wei Wang, Xiuhua Guo |
Journal | Journal of diabetes research
(J Diabetes Res)
Vol. 2020
Pg. 5041346
( 2020)
ISSN: 2314-6753 [Electronic] England |
PMID | 32587867
(Publication Type: Journal Article)
|
Copyright | Copyright © 2020 Zhiyuan Wu et al. |
Chemical References |
- Blood Glucose
- Immunoglobulin G
- Polysaccharides
- glycosylated IgG
|
Topics |
- Adult
- Aged
- Blood Glucose
(metabolism)
- Case-Control Studies
- China
- Diabetes Mellitus, Type 2
(metabolism)
- Down-Regulation
- Female
- Humans
- Immunoglobulin G
(chemistry, metabolism)
- Male
- Middle Aged
- Polysaccharides
(chemistry, metabolism)
- Reproducibility of Results
- Up-Regulation
|