Abstract | OBJECTIVES: METHODS: We retrospectively analyzed patients with acute- and lymphoma-type ATL. Among 57 patients diagnosed with ATL between January 2008 and August 2018, 42 who received salvage therapy were eligible, including 24 who received mogamulizumab. RESULTS: The overall response rate to mogamulizumab was 54.2%. Median survival time (MST) and 1-year overall survival (OS) rate from mogamulizumab initiation were 7.7 months and 42.0%, respectively. Patients with acute-type ATL showed longer MST (15.1 months) and higher 1-year OS (63.6%). MST without skin rash was 5.0 months, and 1-year OS was 34.3%; however, MST with skin rash was not reached and 1-year OS was 66.7%. Among patients who received the salvage therapy, longer MST and higher 1-year OS were observed with mogamulizumab than without mogamulizumab (P = .078; 9.2 vs. 3.9 months; 47.9% vs. 17.6%, respectively). Mogamulizumab administration improved prognosis in patients with acute-type ATL and skin rash. CONCLUSIONS: In clinical practice, mogamulizumab improved OS in patients with relapsed/refractory ATL, especially those with acute-type ATL and skin rash.
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Authors | Atsushi Satake, Akiko Konishi, Yoshiko Azuma, Yukie Tsubokura, Hideaki Yoshimura, Masaaki Hotta, Takahisa Nakanishi, Shinya Fujita, Aya Nakaya, Tomoki Ito, Kazuyoshi Ishii, Shosaku Nomura |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 105
Issue 6
Pg. 704-711
(Dec 2020)
ISSN: 1600-0609 [Electronic] England |
PMID | 32564395
(Publication Type: Journal Article)
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Copyright | © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents, Immunological
- mogamulizumab
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Topics |
- Antibodies, Monoclonal, Humanized
(administration & dosage, adverse effects, therapeutic use)
- Antineoplastic Agents, Immunological
(administration & dosage, adverse effects, therapeutic use)
- Drug Resistance, Neoplasm
- Humans
- Leukemia-Lymphoma, Adult T-Cell
(diagnosis, drug therapy, mortality)
- Molecular Targeted Therapy
- Prognosis
- Recurrence
- Retreatment
- Retrospective Studies
- Treatment Outcome
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