Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma.

Abstract

We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of 10BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of 10B compound as multidisciplinary treatments for HCC.

• Authors: Hironobu Yanagie, Masashi Yanagawa, Tsuyoshi Higuchi, Ryouji Mizumachi, Mitsuteru Fujihara, Yasuyuki Morishita, Yuriko Sakurai, Kikue Mouri, Novriana Dewi, Yasumasa Nonaka, Atsuko Shinohara, Takehisa Matsukawa, Ayano Kubota, Kazuhito Yokoyama, Minoru Suzuki, Shin-Ichiro Masunaga, Yohinori Sakurai, Hiroki Tanaka, Koji Ono, Haruo Yamauchi, Minoru Ono, Jun Nakajima, Shushi Higashi, Hiroyuki Takahashi
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 163 Pg. 109202 (Sep 2020) ISSN: 1872-9800 [Electronic] England
• PMID: 32561043 (Publication Type: Journal Article)
• Copyright: Copyright © 2020. Published by Elsevier Ltd.

Chemical References

• Boron Compounds
• Emulsions
• Oils
• Water

Topics

• Animals
• Boron Compounds (administration & dosage, toxicity)
• Boron Neutron Capture Therapy (methods)
• Carcinoma, Hepatocellular (radiotherapy)
• Emulsions
• Injections, Intra-Arterial
• Liver Neoplasms (radiotherapy)
• Oils
• Rabbits
• Swine
• Water