Abstract |
The aim was to provide evidence on systemically treated patients with advanced melanoma not represented in phase III trials to support clinical decision-making. Analysis were performed on advanced melanoma patients diagnosed between 2014 and 2017 in the Netherlands, treated with immune- or targeted therapy, who met ≥1 trial exclusion criteria. These criteria were derived from the KEYNOTE-006 and CHECKMATE-067/-066 phase III trials. Prognostic importance of factors associated with overall survival (OS) was assessed with the Kaplan-Meier method, Cox models, predicted OS probabilities of prognostic subgroups and a conditional inference survival tree (CIST). A nationwide population-based registry was used as data source. Of 2536 systemically treated patients with advanced melanoma, 1004 (40%) patients were ineligible for phase IIII trials. Ineligible patients had a poorer median OS (mOS) compared to eligible patients (8.8 vs 23 months). Eligibility criteria strongly associated with OS in systemically treated ineligible patients were Eastern Cooperative Oncology Group Performance Score (ECOG PS) ≥2, brain metastases (BM) and lactate dehydrogenase (LDH) of >500 U/L. Patients with ECOG PS of ≥2 with or without symptomatic BM had a predicted mOS of 6.5 and 11.3 months and a 3-year survival probability of 9.3% and 23.6%, respectively. The CIST showed the strongest prognostic covariate for survival was LDH, followed by ECOG PS. The prognosis of patients with LDH of >500 U/L is poor, but long-term survival is possible. The prognosis of ineligible patients with advanced melanoma in real-world was very heterogeneous and highly dependent on LDH value, ECOG PS and symptomatic BM.
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Authors | Michiel C T van Zeijl, Rawa K Ismail, Liesbeth C de Wreede, Alfonsus J M van den Eertwegh, Anthonius de Boer, Maaike van Dartel, Doranne L Hilarius, Maureen J B Aarts, Franchette W P J van den Berkmortel, Marye J Boers-Sonderen, Jan-Willem B de Groot, Geke A P Hospers, Ellen Kapiteijn, Djura Piersma, Rozemarijn S van Rijn, Karijn P M Suijkerbuijk, Albert J Ten Tije, Astrid A M van der Veldt, Gerard Vreugdenhil, John B A G Haanen, Michel W J M Wouters |
Journal | International journal of cancer
(Int J Cancer)
Vol. 147
Issue 12
Pg. 3461-3470
(12 15 2020)
ISSN: 1097-0215 [Electronic] United States |
PMID | 32559817
(Publication Type: Journal Article, Pragmatic Clinical Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. |
Chemical References |
- Antineoplastic Agents, Immunological
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents, Immunological
(therapeutic use)
- Clinical Decision-Making
- Clinical Trials, Phase III as Topic
- Female
- Humans
- Male
- Melanoma
(drug therapy, pathology)
- Middle Aged
- Molecular Targeted Therapy
(methods)
- Neoplasm Staging
- Netherlands
- Patient Selection
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Survival Analysis
- Treatment Outcome
- Young Adult
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