Abstract | BACKGROUND: METHOD: In this study, 120 newborns who were hospitalized for phototherapy were randomly assigned. Group A received phototherapy and UDCA 5 mg/kg/dose every 12 hours orally, group B patients were treated with phototherapy and UDCA 7.5 mg/kg/dose every 12 hours orally. Group C received phototherapy with a placebo. All patients were evaluated for bilirubin levels, the duration of phototherapy, and the length of hospital stay. RESULTS: The mean bilirubin level at hospital admission was 19.88 ± 2.33 mg/dl in group A, 19.33 ± 2.51 mg/ dl in group B, and 19.76 ± 2.64 mg/dl in group C (p= 0.58). The groups receiving phototherapy with UDCA showed a significant decrease in the bilirubin level. Bilirubin level decreased to 10.04 ± 1.11mg/dl in group A, 8.82 ± 1.11 mg/dl in group B, and 12.04 ± 2.05 mg/dl in group C (p= 0.000). Furthermore, the mean duration of phototherapy, as well as the average length of hospital stay, were significantly lower in group B as compared to the other groups (p= 0.000). CONCLUSION:
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Authors | Manizheh Mostafa Gharehbaghi, Afsaneh Mokhallegh Sani, Mandana Refeey |
Journal | The Turkish journal of pediatrics
(Turk J Pediatr)
Vol. 62
Issue 3
Pg. 424-430
( 2020)
ISSN: 2791-6421 [Electronic] Turkey |
PMID | 32558416
(Publication Type: Journal Article)
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Chemical References |
- Ursodeoxycholic Acid
- Bilirubin
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Topics |
- Bilirubin
- Humans
- Hyperbilirubinemia, Neonatal
- Infant, Newborn
- Jaundice
- Jaundice, Neonatal
(drug therapy)
- Phototherapy
- Ursodeoxycholic Acid
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