The aim of this study is to report a patient with
corneal opacity that developed after the use of topical
antiglaucoma medications other than
brimonidine tartrate (BT). An 85-year-old woman presented with
corneal opacity and neovascularization in both eyes. A diagnosis of
glaucoma was made 20 years previously, and
antiglaucoma agents were prescribed (
latanoprost,
tafluprost,
timolol maleate,
travoprost,
bimatoprost,
ripasudil hydrochloride hydrate, and
brinzolamide/
timolol maleate) for both eyes. Ocular examination revealed semicircular fan-shaped corneal sterile infiltration with neovascularization. Anterior-segment optical coherence tomography (OCT) showed marked
corneal opacity and thickened corneal stroma. The topical drugs were discontinued and replaced with 0.1%
betamethasone eye drops. Two weeks after topical drugs were discontinued and replaced with
betamethasone, the corneal sterile infiltration markedly improved, although the
corneal opacity remained across the stromal layer. In addition,
corneal opacity, intermixed with separate transparent sections, was observed as a striped shape. OCT showed an improvement of the thickened corneal stroma. Six weeks after the initial visit, the remaining
corneal opacity could be seen as a mixture of opaque and nonopaque areas in stripes. The corneal stromal thickness decreased almost back to the normal range, while the area of the
corneal opacity remained unchanged. In vivo
laser confocal microscopy showed hyperreflective materials with needle-like structures in the corneal stroma. The
corneal opacity showed several similarities to the previous reports of the cases treated with BT. Therefore, clinicians should be mindful of a possible development of
corneal opacity in patients treated with
antiglaucoma medications other than BT.