Abstract | BACKGROUND: Despite the recognition of food allergies as a significant cause of morbidity and a growing public health burden worldwide, there are no epidemiological studies addressing food sensitization and allergy in Jordan. OBJECTIVE: To conduct an epidemiological study that retrospectively analyzes sensitization data from 3463 patients with suspected immunoglobulin E ( IgE)-mediated food allergic reactions who performed specific IgE tests in our laboratories in Jordan. METHODS: Specific IgE (s- IgE) tests were analyzed for patients who performed enzyme allegro-sorbent testing based on either self-reported food allergy or upon physician's request. RESULTS: 2.3% of the analyzed samples were cross-reactive to carbohydrate determinants. A quarter of the patients were sensitized to one or more food allergens, with males having higher odds of being s- IgE positive. Furthermore, a higher prevalence of sensitization was seen in infants and children compared with adults. s- IgE was most frequently found against cow milk (11.2%), pistachio (4.9%), soybean (4.6%), cherry (4.4%), and orange (4.4%). Interestingly, the s- IgE class distribution profile of pistachio differed from the rest of the top hits being skewed away from the weak class 1 leaning more towards higher IgE classes. Food allergen sensitization was age group-dependent: milk, tree nuts, and eggs were the main food groups causing sensitization in infants, while it was fruits followed by milk in children and adults. CONCLUSIONS: Our work represents the first epidemiological study addressing food sensitization in Jordan. This study lays a solid foundation for future studies that can help better guide food allergy diagnosis, patient dietary modifications, and food elimination plans, as well as assist decision-makers in the region to develop national strategies for an efficient and sustainable healthcare system.
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Authors | Issa Abu-Dayyeh, Jumana Abu-Kwaik, Alf Weimann, Amid Abdelnour |
Journal | Immunity, inflammation and disease
(Immun Inflamm Dis)
Vol. 8
Issue 3
Pg. 384-392
(09 2020)
ISSN: 2050-4527 [Electronic] England |
PMID | 32542909
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Animals
- Female
- Flour
- Food Hypersensitivity
- Humans
- Immunoglobulin E
- Jordan
- Male
- Prevalence
- Retrospective Studies
- Triticum
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