Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells.

Abstract

We report the synthesis and comprehensive characterization of a new platinum-AIEgen coordination complex. Possessing a high 1O2 quantum yield of 0.75 in water, the complex efficiently kills cisplatin-resistant cancer cells under mild white light irradiation. Its strong fluorescence upon binding with proteins also enables direct visualization of its intracellular distribution.

• Authors: Zhenyan He, Yuting Gao, Haoke Zhang, Xiuxia Wang, Fanling Meng, Liang Luo, Ben Zhong Tang
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 56 Issue 56 Pg. 7785-7788 (Jul 14 2020) ISSN: 1364-548X [Electronic] England
• PMID: 32542273 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Coordination Complexes
• Platinum
• Cisplatin

Topics

• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Cisplatin (pharmacology)
• Coordination Complexes (chemistry)
• Drug Resistance, Neoplasm (drug effects)
• Humans
• Molecular Imaging (methods)
• Platinum (chemistry)