Clinical Characteristics of Systemic Lupus Erythematosus with Cirrhosis.

Abstract

AIM:

Cirrhosis is rare in systemic lupus erythematosus (SLE) patients with a poor prognosis. This study is aimed at retrospectively analyzing our single-center experience to explore the characteristics of cirrhosis in SLE patients.

METHODS:

SLE patients with cirrhosis from 2012 to 2019 were enrolled. SLE diagnosis was rigorously confirmed by a medical record review according to the revised 1997 American College of Rheumatology classification criteria for SLE. The diagnosis of liver cirrhosis was based on a combination of clinical, laboratory, and imaging criteria features. We conducted a case-control study in SLE patients complicated with the cirrhosis group and the age-, sex-, and entry-time-matched noncirrhosis group.

RESULTS:

A total of 21 patients with SLE cirrhosis were enrolled, 3 males and 18 females. The median age at the time of cirrhosis diagnosis was 47.3 ± 4.0 years, and the mean disease duration of SLE before cirrhosis was 4.7 ± 1.0 years. The most common initial presentation was the involvement of the hematological system in 9 patients and then skin and mucosal involvement in 5 patients, arthritis in 4 patients, and nephritis in 3 patients. Patients with cirrhosis had a significantly higher rate of hematological system involvement (thrombocytopenia and leukopenia) and worse liver function; a higher level of immune globulin G had higher mortality (p < 0.05) than patients without cirrhosis.

CONCLUSIONS:

Cirrhosis is a rare and severe subtype of SLE with a poor prognosis. Those patients with hematological system involvement and impaired liver function should be paid more attention.

• Authors: Hanxiao You, Linyi Peng, Jiuliang Zhao, Yunyun Fei, Qian Wang, Wen Zhang, Mengtao Li, Xiaofeng Zeng
• Journal: Journal of immunology research (J Immunol Res) Vol. 2020 Pg. 2156762 ( 2020) ISSN: 2314-7156 [Electronic] Egypt
• PMID: 32537465 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Hanxiao You et al.

Chemical References

• Immunoglobulin G

Topics

• Adult
• Case-Control Studies
• Female
• Humans
• Immunoglobulin G (blood)
• Leukopenia
• Liver (metabolism, pathology)
• Liver Cirrhosis (complications, mortality, physiopathology)
• Lupus Erythematosus, Systemic (complications, mortality, physiopathology)
• Male
• Middle Aged
• Retrospective Studies
• Skin (pathology)
• Survival Analysis
• Thrombocytopenia