Immunohistochemical results and case report of an incidental finding of uterine polypoid adenomyoma after long-time therapy for metrorrhagia.

Abstract

We present a 25-year-old female woman with a 9-year history of metrorrhagia, in whom a uterine polypoid adenomyoma (UPA) was incidentally detected. Intense nuclear staining in the uterine adenomyoma tissue showed an immunoreaction with BAF250a/ARID1A, Arginase-2 as well as 1LRH-2E1/NR5A2, suggesting a role of these proteins and transcriptional activity of their genes in uterine polypoid adenomyoma development. Neither Nidogen-2 nor SF-1/NR5A1 were expressed in UPA.

• Authors: Wiktor Szewczuk, Oksana Szewczuk, Krzysztof Czajkowski, Bartłomiej Grala, Andrzej Semczuk
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 216 Issue 7 Pg. 152998 (Jul 2020) ISSN: 1618-0631 [Electronic] Germany
• PMID: 32534705 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor

Topics

• Adenomyoma (complications, diagnosis, pathology)
• Adult
• Biomarkers, Tumor (analysis)
• Female
• Humans
• Immunohistochemistry
• Incidental Findings
• Metrorrhagia (complications)
• Uterine Neoplasms (complications, diagnosis, pathology)