Comparison of the efficacy and impact of GEMOX and GDP in the treatment of patients with non-Hodgkin's lymphoma.

Abstract

PURPOSE:

To compare the efficacy and impact of GEMOX and GDP in the treatment of patients with non-Hodgkin's lymphoma (NHL).

METHODS:

A total of 68 patients with NHL admitted to the hospitals of the authors from February 2013 to April 2016 were equally distributed into the GEMOX Group (treated with Gemcitabine and Oxaliplatin) and the GDP Group (treated with Gemcitabine, Cisplatin, and Dexamethasone), with cycle repetition every 3 weeks. The efficacy was analyzed every two weeks. The side effects were analyzed once a week. Comparison of survival was performed using Kaplan-Meier method and log-rank test and Cox univariate and multivariate regression analyses.

RESULTS:

Efficacy in the two groups was not statistically different (p>0.05). The incidence of III-IV grade of nausea and vomiting in the GDP Group was higher than in the GEMOX Group (p<0.05). The overall incidence decreased hemoglobin, nausea and vomiting, and renal dysfunction of the GDP Group was also higher than in the GEMOX Group (p<0.05). Analysis by multivariate Cox model found that the clinical classification and the grade of malignancy were independent prognostic factors (p<0.05). The odds ratio (OR) values of the clinical classification in the GEMOX Group and the GDP Group were 2.874 and 24.074, respectively. The OR values of the grade of malignancy in the GEMOX Group and the GDP Group were 14.034 and 6.873, respectively.

CONCLUSION:

Both the GEMOX regimen and the GDP regimen had good short-term efficacy on NHL patients, but the GEMOX regimen is to be preferred since as it had fewer side effects than the GDP regimen.

• Authors: Xingxia Zhang, Baoran Wang, Weiguo Tao, Yejun Si, Guoqiang Lin, Yanming Zhang, Ran Liu, Wenzhi Yuan
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2020 Mar-Apr Vol. 25 Issue 2 Pg. 1042-1049 ISSN: 2241-6293 [Electronic] Cyprus
• PMID: 32521904 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Organoplatinum Compounds
• Deoxycytidine
• Dexamethasone
• Cisplatin
• Gemcitabine

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Cisplatin (administration & dosage, adverse effects)
• Deoxycytidine (administration & dosage, adverse effects, analogs & derivatives)
• Dexamethasone (administration & dosage, adverse effects)
• Female
• Humans
• Lymphoma, Non-Hodgkin (drug therapy)
• Middle Aged
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Treatment Outcome
• Young Adult
• Gemcitabine