A Multicenter Investigation Examining American Urological Association Recommended Antibiotic Prophylaxis vs Nonstandard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients.
Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Standard AUA antibiotic prophylaxis was followed in 48.6% (391) of cases while nonstandard prophylaxis was used in 51.4% (413). Common nonstandard antibiotic prophylaxis included vancomycin- gentamycin- fluoroquinolone, clindamycin- fluoroquinolone, and vancomycin- fluoroquinolone among other combinations. Patients who received AUA prophylaxis had significantly more postoperative device infections (5.6% vs 1.9%, p <0.01) and explantations (8.3% vs 2.0%, p <0.001) compared to those who received nonstandard prophylaxis. Patients who received AUA prophylaxis had significantly higher odds of a postoperative device infection (OR 2.8, 95% CI 1.1-7.3) and explantation (OR 3.6, 95% CI 1.4-9.1) compared to those who received nonstandard prophylaxis. CONCLUSIONS: Diabetic men with erectile dysfunction who received standard AUA prophylaxis for penile prosthesis surgery had significantly greater odds of experiencing a postoperative device infection and device explantation compared to patients who received nonstandard prophylaxis. Our study provides a strong rationale for a prospective investigation to establish the most appropriate prophylaxis strategy in penile prosthesis surgery.
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Authors | Michael E Rezaee, Maxwell Towe, Mohamad M Osman, Linda M Huynh, Farouk M El-Khatib, Robert Andrianne, Gregory Broderick, Arthur L Burnett, Martin S Gross, Amy I Guise, Georgios Hatzichristodoulou, Gerard D Henry, Jonathan Clavell-Hernandez, Tung-Chin Hsieh, Lawrence C Jenkins, Aaron Lentz, Ricardo M Munarriz, Daniar Osmonov, Sung Hun Park, Paul Perito, Hossein Sadeghi-Nejad, Maxime Sempels, Jay Simhan, Run Wang, Faysal A Yafi |
Journal | The Journal of urology
(J Urol)
Vol. 204
Issue 5
Pg. 969-975
(Nov 2020)
ISSN: 1527-3792 [Electronic] United States |
PMID | 32519913
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
(methods, standards, statistics & numerical data)
- Diabetes Mellitus
(immunology)
- Drug Therapy, Combination
(methods, standards, statistics & numerical data)
- Erectile Dysfunction
(surgery)
- Europe
(epidemiology)
- Humans
- Male
- Middle Aged
- Penile Prosthesis
(adverse effects)
- Practice Guidelines as Topic
- Prospective Studies
- Prosthesis Implantation
(adverse effects, instrumentation)
- Prosthesis-Related Infections
(epidemiology, immunology, microbiology, prevention & control)
- Reoperation
(statistics & numerical data)
- Republic of Korea
(epidemiology)
- Retrospective Studies
- Societies, Medical
(standards)
- Treatment Outcome
- United States
(epidemiology)
- Urology
(standards)
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