Elevated CXCL10 Serum Levels in Measles Virus Primary Infection and Reinfection Correlate With the Serological Stage and Hospitalization Status.

Abstract

We quantified serum concentrations of chemokine CXCL10 in 288 patients with measles virus (MeV) primary infection and 16 patients with reinfection (vaccine failure). CXCL10 peaked with emergence of IgM antibodies and was elevated in hospitalized patients (3233 vs 1930 pg/mL, P < .0001). CXCL10 differed between primary and reinfection (1958 vs 932 pg/mL, P = .0402). In comparison to other viral infections with rash-like symptoms, CXCL10 was highly elevated in MeV infection (area under the curve = 0.935; 95% confidence interval, .905-.965; P < .0001). CXCL10 is a potential marker for diagnosis, stage, and severity of MeV infection.

• Authors: Georg Semmler, Hannah Griebler, Stephan W Aberle, Karin Stiasny, Lukas Richter, Heidemarie Holzmann, Lukas Weseslindtner
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 222 Issue 12 Pg. 2030-2034 (11 13 2020) ISSN: 1537-6613 [Electronic] United States
• PMID: 32515478 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Antibodies, Viral
• Biomarkers
• CXCL10 protein, human
• Chemokine CXCL10
• Immunoglobulin M

Topics

• Antibodies, Viral (blood)
• Biomarkers (blood)
• Chemokine CXCL10 (blood)
• Hospitalization
• Humans
• Immunoglobulin M (blood)
• Measles (immunology)
• Reinfection (blood, virology)