Initial multicenter experience with nitrous oxide cryoballoon for treatment of flat duodenal adenomas (with video).

Abstract

BACKGROUND AND AIMS:

EMR is the preferred endoscopic therapy for duodenal adenomas (DAs) but is associated with an overall adverse event rate of 26%. Cryotherapy using a Cryoballoon Focal Ablation System (CbFAS) can safely and effectively eradicate esophageal intestinal metaplasia. We report our first experience with cryoballoon ablation for treatment of flat DAs.

METHODS:

This was an American, multicenter, retrospective study involving 5 centers. DAs (Paris 0-IIa and 0-IIb) were treated with nitrous oxide for 5 to 12 seconds using CbFAS. Follow-up EGD was performed at 3 to 12 months.

RESULTS:

Seventeen DAs (mean size, 22.7 ± 14.3 mm; 12 tubular, 5 tubulovillous) from 13 patients (mean age, 66.5 ± 9.99 years; 61.5% males) were included in the study. Thirteen of 17 DAs (76.5%) had failed previous treatment, and 4 of 17 (23.5%) were treatment naÏve. All procedures were technically successful and achieved a >50% decrease in size after cryoballoon ablation There was no increase in size or progression of disease for any lesions. Overall, treatment was completed in 15 of 17 patients, and recurrence-free survival was achieved in 12 of 17 (71%) after a median follow-up of 15.5 months (interquartile range [IQR], 6.8-19.4). The median cryoablation time per polyp was 4 minutes (IQR, 1-7.5 minutes), and the median total procedure time was 25 minutes (IQR, 22-30.5 minutes). There were no intra- or postprocedural adverse events.

CONCLUSIONS:

Nitrous oxide cryoballoon ablation of nonpolypoid DAs is feasible, with promising safety and efficacy.

• Authors: Mohamad Dbouk, Olaya Brewer Guiterrez, Arvind J Trindade, David L Diehl, Richard S Kwon, Nirav C Thosani, Harshit S Khara, Petros C Benias, Tossapol Kerdsirichairat, Marcia Irene Canto
• Journal: Gastrointestinal endoscopy (Gastrointest Endosc) Vol. 93 Issue 1 Pg. 240-246 (01 2021) ISSN: 1097-6779 [Electronic] United States
• PMID: 32511958 (Publication Type: Journal Article, Multicenter Study, Video-Audio Media)
• Copyright: Copyright © 2021 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

Chemical References

• Nitrous Oxide

Topics

• Adenoma (surgery)
• Aged
• Atrial Fibrillation
• Catheter Ablation
• Cryosurgery
• Female
• Humans
• Male
• Middle Aged
• Nitrous Oxide
• Retrospective Studies
• Treatment Outcome