Introduction The immunosuppressive nature of some
cancers and many
cancer-directed treatments may increase the risk of
infection with and severe sequelae from
Coronavirus Disease 2019 (COVID-19). The objective of this study was to compare concerns about
COVID-19 among individuals undergoing
cancer treatment to those with a history of
cancer not currently receiving
therapy and to those without a
cancer history. Methods We conducted a cross-sectional anonymous online survey study of adults currently residing in the United States. Participants were recruited over a one-week period (April 3-11, 2020) using promoted advertisements on Facebook and Twitter. Groups were compared using chi-squared tests, Fisher's exact tests, and t-tests. Results 543 respondents from 47 states provided information on their
cancer history and were included in analyses. Participants receiving active treatment reported greater concern about
coronavirus infection (p<0.0001), higher levels of family distress caused by the
COVID-19 pandemic (p=0.004), and greater concern that the general public does not adequately understand the seriousness of
COVID-19 (p=0.04). Those with metastatic disease were more likely to indicate that
COVID-19 had negatively affected their
cancer care compared to patients with non-metastatic
cancer (50.8% vs. 31.0%; p=0.02). The most commonly reported treatment modifications included
chemotherapy delays. Conclusions Patients undergoing active treatment for
cancer were most concerned about the short-term effects of the
COVID-19 pandemic on the logistics as well as potential efficacy of ongoing
cancer treatment, longer term effects, and overarching societal concerns that the population at large is not as concerned about the public health implications of the coronavirus.