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Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy.

Abstract
Current metastatic breast cancer therapies are not only affected by limited drug delivery options, but also restricted to the monotherapies. Here, we synthesized trimethyl chitosan (TMC), loaded it with photosensitizer IR780 or bufalin by ionic gelation, and coated it with human serum albumin (HSA) by electrostatic absorption (designated TIH or TBH, respectively). The near-spherical nanoparticles had a size of approximately 30 nm, exerted strong photothermal effects, and enhanced cellular mitochondrion colocation and phototoxicity. Tumor microenvironments were disrupted by TIH-mediated photothermal effects, which enhanced the accumulation of a second TBH dose in the tumor that promoted deep penetration in the whole tumor mass. After laser irradiation our nanoplatform enhanced cancer tissue accessibility and substantially suppressed tumor growth, and causing a 98.46 % inhibition of lung metastasis. Thus HSA-masked TMC represents a promising tumor-targeted drug delivery strategy with synergistic modality that may improve the therapeutic outcome of metastatic breast cancer.
AuthorsHaiyan Hu, Qi Qi, Ziyi Dong, Xianglong Yu, Yujia Mo, Juyuan Luo, Yan Wang, Shouying Du, Yang Lu
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 241 Pg. 116335 (Aug 01 2020) ISSN: 1879-1344 [Electronic] England
PMID32507205 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Elsevier Ltd. All rights reserved.
Chemical References
  • 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium
  • Bufanolides
  • Drug Carriers
  • Indoles
  • N-trimethyl chitosan chloride
  • Photosensitizing Agents
  • Chitosan
  • bufalin
Topics
  • Animals
  • Bufanolides (pharmacology, therapeutic use)
  • Cell Line, Tumor
  • Chitosan (chemistry)
  • Drug Carriers (chemistry)
  • Female
  • Indoles (pharmacology, therapeutic use)
  • Mammary Neoplasms, Experimental (drug therapy)
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles (chemistry)
  • Photochemotherapy
  • Photosensitizing Agents (pharmacology, therapeutic use)
  • Photothermal Therapy
  • Tumor Microenvironment (drug effects)

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