MiR-145 in cancer therapy resistance and sensitivity: A comprehensive review.

Abstract

MircoRNA (miRNA) are a group of small, non-coding, regulatory RNA with an average length of approximately 22 nucleotides, which mostly modulate gene expression post-transcriptionally through complementary binding to the 3'-untranslated region (3'-UTR) of multiple target genes. Emerging evidence has shown that miRNA are frequently dysregulated in a variety of human malignancies. Among them, microRNA-145 (miR-145) has been increasingly identified as a critical suppressor of carcinogenesis and therapeutic resistance. Resistance to tumor therapy is a challenge in cancer treatment due to the daunting range of resistance mechanisms. We reviewed the status quo of recent advancements in the knowledge of the functional role of miR-145 in therapeutic resistance and the tumor microenvironment. It may serve as an innovative biomarker for therapeutic response and cancer prognosis.

• Authors: Wenxiu Xu, Yuting Hua, Fei Deng, Dandan Wang, Yang Wu, Wei Zhang, Jinhai Tang
• Journal: Cancer science (Cancer Sci) Vol. 111 Issue 9 Pg. 3122-3131 (Sep 2020) ISSN: 1349-7006 [Electronic] England
• PMID: 32506767 (Publication Type: Journal Article, Review)
• Copyright: © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• 3' Untranslated Regions
• Biomarkers, Tumor
• MIRN145 microRNA, human
• MicroRNAs
• RNA, Messenger

Topics

• 3' Untranslated Regions
• Biomarkers, Tumor
• Computational Biology (methods)
• Drug Resistance, Neoplasm (genetics)
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Humans
• MicroRNAs
• Neoplasms (genetics, metabolism, pathology, therapy)
• RNA Interference
• RNA, Messenger
• Radiation Tolerance (genetics)