Prognostic significance of vasohibin-1 and vasohibin-2 immunohistochemical expression in gastric cancer.

Abstract

PURPOSE:

It was recently identified that the vasohibin family may regulate angiogenesis through suppression by the vasohibin-1 gene and promotion by the vasohibin-2 gene. We assessed vasohibin expression in gastric cancer patients and its effect on their prognosis.

METHODS:

We evaluated vasohibin immunohistochemical expression in 210 patients with gastric cancer, who underwent radical surgery. The patients were divided first into a vasohibin-1-positive group and a vasohibin-1-negative group, and then into groups with high or low vasohibin-2 expression, to allow us to investigate the clinicopathological factors of prognosis retrospectively.

RESULTS:

There were 139 patients in the vasohibin-1-positive group and 71 patients in the vasohibin-1-negative group, among which there were and 108 with high vasohibin-2 expression and 102 with low vasohibin-2 expression. Vasohibin-1 was associated with Ly (P = 0.003) and pT (P = 0.037), whereas vasohibin-2 was associated with Ly (P < 0.001), V (P < 0.001) and pStage (P < 0.001). Overall, cancer-specific and relapse-free survival rates were lower in the vasohibin-1-positive (P = 0.034, P < 0.001, P = 0.002, respectively) and high vasohibin-2 expression (P = 0.004, P = 0.003, P < 0.001, respectively) groups. Multivariate analysis revealed that vasohibin-1 expression was associated with cancer-specific (P = 0.014, hazard ratio [HR] 4.454) and relapse-free (P = 0.035, HR 2.557) survival and vasohibin-2 expression tended to influence relapse-free survival (P = 0.051, HR 2.061). Grouping patients by vasohibin expression status combinations showed correlation among their expressions (P = 0.005). Overall, cancer-specific and relapse-free survival rates were lowest in the vasohibin-1-positive and high vasohibin-2 expression group.

CONCLUSION:

Our findings demonstrate that vasohibin-1 and vasohibin-2 could be novel biomarkers for predicting gastric cancer prognosis.

• Authors: Hitoshi Hara, Soji Ozawa, Yamato Ninomiya, Miho Yamamoto, Mika Ogimi, Kazuhito Nabeshima, Kenji Nakamura, Hiroshi Kajiwara, Naoya Nakamura, Yasufumi Sato
• Journal: Surgery today (Surg Today) Vol. 50 Issue 11 Pg. 1530-1543 (Nov 2020) ISSN: 1436-2813 [Electronic] Japan
• PMID: 32494966 (Publication Type: Journal Article)

Chemical References

• Angiogenic Proteins
• Biomarkers, Tumor
• Cell Cycle Proteins
• VASH1 protein, human
• VASH2 protein, human

Topics

• Aged
• Angiogenic Proteins (genetics, metabolism)
• Biomarkers, Tumor (genetics, metabolism)
• Cell Cycle Proteins (genetics, metabolism)
• Disease-Free Survival
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• Male
• Neoplasm Recurrence, Local (genetics)
• Neovascularization, Pathologic (genetics)
• Prognosis
• Stomach Neoplasms (diagnosis, genetics, mortality, pathology)