Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer.

Abstract

BACKGROUND:

Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis.

PURPOSE:

Research into the combined use of photosensitizers and non-cytotoxic antineoplastic drugs for the safe treatment of triple-negative breast cancer is vital.

METHODS:

In this study, the photosensitizer indocyanine green and the natural drug parthenolide were co-loaded into thermosensitive liposomes. Under a near-infrared irradiation, indocyanine green reached excitation levels, releasing heat, and the liposome underwent a phase transition, releasing the drug were researched.

RESULTS:

Thus, indocyanine green and parthenolide exert synergistic antineoplastic effects. In the nude mice xenograft MDA-MB-231 tumor model, the tumor inhibition rate of indocyanine green-parthenolide thermosensitive liposomes was approximately 2.08-fold than that of paclitaxel and demonstrated a good initial safety evaluation.

CONCLUSION:

Photosensitizers and non-cytotoxic antineoplastic agents in combination with nanoscale carriers should be further investigated for the treatment of tumors.

• Authors: Xin Jin, Xinyue Lu, Zhenhai Zhang, Huixia Lv
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 15 Pg. 3193-3206 ( 2020) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 32440118 (Publication Type: Journal Article)
• Copyright: © 2020 Jin et al.

Chemical References

• Antineoplastic Agents
• Liposomes
• Photosensitizing Agents
• Reactive Oxygen Species
• Sesquiterpenes
• parthenolide
• Indocyanine Green
• Paclitaxel

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacology, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Apoptosis (drug effects)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Drug Delivery Systems
• Endocytosis (drug effects)
• Female
• Humans
• Hydrodynamics
• Indocyanine Green (administration & dosage, pharmacology, therapeutic use)
• Liposomes
• Mice, Inbred BALB C
• Mice, Nude
• Paclitaxel (therapeutic use)
• Photosensitizing Agents (therapeutic use)
• Reactive Oxygen Species (metabolism)
• Sesquiterpenes (pharmacology, therapeutic use)
• Temperature
• Tissue Distribution (drug effects)
• Treatment Outcome
• Triple Negative Breast Neoplasms (drug therapy, pathology)
• Tumor Burden (drug effects)