Abstract | BACKGROUND: METHODS: Twenty four Wistar rats were divided into three groups as follows: control group (Group 1), fondaparinux group (Group 2) and dabigatran group (Group 3). A model of a degloving injury on the tail of rats was developed in all groups. After 15 minutes, the avulsed flaps were sutured back. Group 1 received 1ml/day saline intraperitoneally for 10 days. Group 2 received 0.3 ml/kg/day fondaparinux intraperitoneally for 10 days. Group 3 received 30 mg/kg/day dabigatran orally for 10 days. At the end of the treatments, gross morphological and histopathological tail tissue survivals were evaluated. RESULTS: CONCLUSION:
Dabigatran and fondaparinux improved tissue survival in skin degloving injuries concerning gross morphological and histopathological findings. However, the findings of this study should be supported and improved by new experimental and especially clinical studies.
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Authors | Alper Ural, Fatma Bilgen, Duygun Altıntaş Aykan, Abdulkadir Yasir Bahar, Mehmet Bekerecioğlu, Dilan Altıntaş Ural |
Journal | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
(Ulus Travma Acil Cerrahi Derg)
Vol. 26
Issue 3
Pg. 343-350
(May 2020)
ISSN: 1307-7945 [Electronic] Turkey |
Vernacular Title | Avülsiyon yaralanmalarında fondaparinuks ve dabigatranın etkileri: Deneysel bir çalışma. |
PMID | 32436968
(Publication Type: Journal Article)
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Chemical References |
- Antithrombins
- Dabigatran
- Fondaparinux
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Topics |
- Animals
- Antithrombins
(administration & dosage, therapeutic use)
- Dabigatran
(administration & dosage, therapeutic use)
- Degloving Injuries
(drug therapy, pathology)
- Fondaparinux
(administration & dosage, therapeutic use)
- Male
- Rats
- Rats, Wistar
- Tail
(injuries)
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